Prompt Praxis Labs helps you in designing, developing, implementing and managing an effective, safe and secure Analytical Testing Program for a Pharma Product. We offer the test methods listed below for analyzing a product’s strength, quality, purity, potency, and identity. We also provide services for analytical characterization, bioanalytical services, method development and validation, as well as method transfer and assistance.
Click on each test method to see a sample chromatogram.
Magnesium citrate is a laxative used in bowel preparation for colonoscopy or as a magnesium supplement. ****
Magnesium sulfate is a drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. ****
Meperidine is an opioid agonist with analgesic and sedative properties used to manage severe pain.****
Mepivacaine is a local anesthetic used for local or regional analgesia or anesthesia. A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168). ****
Methadone is an opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.****
Methohexital is an anesthetic used to induce deep sedation. An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. ****
Methotrexate is a medication used to treat cancer, autoimmune diseases, and ectopic pregnancy. It works by inhibiting the metabolism of folic acid, which is necessary for the synthesis of DNA.*
Methylene blue is an oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. ****
Metoclopramide is an antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. ****
Metoprolol is a beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. ****
Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. ****
Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. ****
Mitomycin is an antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies. ****
Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. ****
Moxifloxacin is a fluoroquinolone antibiotic used to treat various bacterial infections. Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. ****
Nalbuphine is an opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. ****
Naloxone is a medication used to rapidly reverse opioid overdose. It works by binding to opioid receptors and blocking the effects of opioid drugs, effectively reversing respiratory depression and other symptoms of overdose.*
Nicardipine is a calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. ****
Neostigmine is a cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. ****
Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures. ****
Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. ****
Naltrexone is a medication used to treat alcohol and opioid dependence. It works by blocking the euphoric and sedative effects of drugs such as heroin, morphine, and alcohol.*
Niacinamide, also known as nicotinamide, is a form of vitamin B3 used to prevent and treat niacin deficiency (pellagra). It is also used in skincare products for its anti-inflammatory properties.*
Ondansetron is a serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. ****
Oxymetazoline is an alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. ****
Oxytocin is a recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding. ****
Oxytocin is a recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding. ****
Pantoprazole is a proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. ****
Parabens are a class of widely used preservatives in cosmetic and pharmaceutical products. Chemically, they are a series of parahydroxybenzoates or esters of parahydroxybenzoic acid (also known as 4-hydroxybenzoic acid). Parabens are effective preservatives in many types of formulas. These compounds, and their salts, are used primarily for their bactericidal and fungicidal properties. They are found in shampoos, commercial moisturizers, shaving gels, personal lubricants, topical/parenteral pharmaceuticals, suntan products, makeup, and toothpaste. They are also used as food preservatives. ***
Phenylephrine is an alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. ****
Piperacillin is a broad-spectrum beta-lactam antibiotic used to treat various bacterial infections, including those of the respiratory tract, urinary tract, and skin. It is often combined with tazobactam to increase its effectiveness.*
Potassium chloride is a mineral supplement used to prevent or treat low levels of potassium in the blood. It is essential for maintaining proper cell function, muscle contraction, and nerve transmission. It is analyzed using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES).*
Potassium phosphate dibasic is used similarly to potassium phosphate monobasic to treat or prevent low levels of phosphate in the blood and is analyzed using titration methods.*
Potassium phosphate monobasic is a phosphate supplement used to treat or prevent low levels of phosphate in the blood. It is essential for energy production and bone health. It is analyzed using titration methods.*
Povidone-iodine is an antiseptic used to disinfect the skin before surgery and to treat minor wounds. It works by releasing iodine, which kills bacteria, viruses, and fungi. It is analyzed using titration methods.*
Prednisolone sodium phosphate is a corticosteroid used to treat various inflammatory and autoimmune conditions, including asthma, allergies, and arthritis. It works by reducing inflammation and suppressing the immune system.*
Prilocaine is a local anesthetic used in dental procedures. It is a local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165). ****
Procaine is a local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. ****
Propofol is a medication used in general anesthesia and for sedation. ****
Propranolol is a non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. ****
Protirelin, also known as thyrotropin-releasing hormone (TRH), is a synthetic hormone used to test the function of the thyroid gland. It stimulates the release of thyroid-stimulating hormone (TSH) from the pituitary gland.*
Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.2,11 Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.11,14
The prevalence of GERD is thought to be 10-20% in western countries.4 Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.5,11 ****
Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia. ****
Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium. ****
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.2 ****
Semaglutide is a medication used to treat type 2 diabetes by mimicking the action of the hormone GLP-1, which increases insulin secretion and decreases glucose production in the liver.*
Sodium bicarbonate is a compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock. ****
Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines. ****
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups.2 It has been widely used for over 50 years,1 most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.9 ****
Sufentanil is an opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. ****
Bupivacaine is a local anesthetic used in a wide variety of superficial and invasive procedures. ****
Ropivacaine is an amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. ****
Sugammadex is a medication used to reverse the effects of certain muscle relaxants used during surgery. It works by binding to the muscle relaxants and preventing them from affecting the muscles.*
Tacrolimus is an immunosuppressive medication used to prevent organ rejection after a transplant. It works by inhibiting the activity of T-cells, which are part of the immune system.*
Tazobactam is a beta-lactamase inhibitor used in combination with other antibiotics, such as piperacillin, to treat bacterial infections. It works by preventing bacteria from breaking down the antibiotics.*
Terbutaline is a beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. ****
This combination of testosterone and anastrozole is used in hormone therapy, particularly for treating conditions such as low testosterone levels and certain types of breast cancer.*
Tetracaine is a local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. ****
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD. ****
Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue. ****
Tirzepatide is a medication used to treat type 2 diabetes by mimicking the action of the hormones GLP-1 and GIP, which increase insulin secretion and decrease glucose production in the liver.*
Tranexamic acid is a medication used to treat or prevent excessive bleeding by inhibiting the breakdown of blood clots. It is commonly used in surgeries and for conditions such as heavy menstrual bleeding.*
Vancomycin is a glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections. ****
Vecuronium is a nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures. ****
Vasopressin is a peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy. ****
Zaltrap, also known as aflibercept, is a medication used to treat certain types of cancer by inhibiting the growth of blood vessels that feed tumors. It is often used in combination with other cancer treatments.*
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